منابع مشابه
Hemostatic Dysfunction in Liver Diseases.
The liver plays a central role in hemostasis, as it is the site of synthesis of most procoagulant and anticoagulant factors. It also synthesizes many fibrinolytic proteins, and is an important source of thrombopoietin. Furthermore, it is involved in clearance of many hemostatic and fibrinolytic components. Consequently, patients with a decreased synthetic capacity of the liver acquire a complex...
متن کاملHemostatic abnormalities and liver diseases.
Professor Eberhard F. Mammen greatly contributed to the understanding of the relationship between hemostatic abnormalities and liver diseases. The physiology of the hemostatic system is closely linked to liver function because the liver parenchymal cells produce most of the factors of the clotting and fibrinolytic systems. Acute or chronic hepatocellular diseases and hepatic failure including l...
متن کاملMitochondrial dysfunction in cholestatic liver diseases.
Cholestatic liver diseases are characterized by blockade of bile flow from the liver to the intestine, and accumulation of hydrophobic bile acids in the liver and plasma. As a consequence an inflammatory response evolves associated with increased apoptosis, oxidative stress, and eventually fibrosis. Cholestasis is associated with profound metabolic changes, alterations in the mitochondrial func...
متن کاملHemostatic dysfunction in paraproteinemias and amyloidosis.
Thrombotic and hemorrhagic complications frequently have been observed in patients with monoclonal gammopathy, Waldenström macroglobulinemia, amyloidosis, multiple myeloma (MM), and myeloma. Chemotherapy in combination with the use of antiangiogenic agents can further enhance the risk of cardiovascular complications. A malignancy-associated thrombophilic state (in particular, cytokine-induced h...
متن کاملHemostatic defects in end stage liver disease.
End stage liver disease results in a complex and variably severe failure of hemostasis that predisposes to abnormal bleeding. The diverse spectrum of hemostatic defects includes impaired synthesis of clotting factors, excessive fibrinolysis, disseminated intravascular coagulation, thrombocytopenia, and platelet dysfunction. Hemostasis screening tests are used to assess disease severity and moni...
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ژورنال
عنوان ژورنال: Seminars in Thrombosis and Hemostasis
سال: 2015
ISSN: 0094-6176,1098-9064
DOI: 10.1055/s-0035-1550441